Talk:Nightmare Mode (SAS4)/@comment-71.12.185.142-20150426032009/@comment-1763304-20150427012722

Around level 50 to 56, they give great loot, but I've noticed a decline in the quality after that for me. I'm level 66 and I get so many 10** Medusa armors of some kind from Nanotaniums most of the time that I hope I never see another one as long as I live.

So I'd say level 48 to 56 is the best time to open Nanotaniums and expect something you may want from them.